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Jon C Aster Selected Research

Notch Receptors

1/2020NOTCH SIGNALING IN CONTEXT: BASIC AND TRANSLATIONAL IMPLICATIONS.
10/2011Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma.
1/2011Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation.
3/2010Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells.
2/2007Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription.
10/2004JAGGED1 expression is associated with prostate cancer metastasis and recurrence.
2/2004Multiple niches for Notch in cancer: context is everything.
1/2003Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling.

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Jon C Aster Research Topics

Disease

62Neoplasms (Cancer)
12/2022 - 01/2002
20Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
01/2020 - 01/2003
17Leukemia
01/2020 - 02/2003
16Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2021 - 11/2004
9Lymphoma (Lymphomas)
12/2022 - 06/2003
6Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
12/2022 - 02/2005
6Hematologic Neoplasms (Hematological Malignancy)
11/2019 - 01/2010
5Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2020 - 11/2006
5T-Cell Lymphoma (Lymphoma, T Cell)
10/2019 - 02/2009
5Non-Hodgkin Lymphoma (Lymphosarcoma)
01/2019 - 03/2010
4B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
12/2021 - 11/2010
4Disease Progression
01/2021 - 05/2007
4Inflammation (Inflammations)
10/2020 - 06/2007
4Melanoma (Melanoma, Malignant)
01/2018 - 02/2005
4Carcinoma (Carcinomatosis)
03/2014 - 06/2008
4Genetic Translocation (Chromosomal Translocation)
11/2004 - 09/2002
3B-Cell Lymphoma (Lymphoma, B Cell)
01/2019 - 08/2005
3Carcinogenesis
10/2014 - 02/2003
3Infections
09/2011 - 04/2004
2Sarcoma (Soft Tissue Sarcoma)
01/2020 - 01/2019
2Atherosclerosis
01/2019 - 07/2012
2Triple Negative Breast Neoplasms
01/2019 - 10/2014
2Neutropenia
01/2018 - 04/2015
2Adenoid Cystic Carcinoma (Cylindroma)
03/2016 - 10/2014
2Squamous Cell Carcinoma (Epidermoid Carcinoma)
03/2014 - 10/2011
2T-Cell Leukemia (Leukemia, T Cell)
11/2012 - 07/2007
2Myeloproliferative Disorders (Myeloproliferative Disorder)
10/2008 - 12/2003
2Hodgkin Disease (Hodgkin's Disease)
08/2005 - 02/2005
2Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma)
02/2005 - 09/2002
1Glomus Tumor (Glomus Tumors)
01/2022
1Marginal Zone B-Cell Lymphoma (MALT Lymphoma)
12/2021
1Communicable Diseases (Infectious Diseases)
01/2021
1Edema (Dropsy)
10/2020
1Myofibroma
04/2020
1Glucocorticoid Receptor Deficiency
01/2020
1Adenocarcinoma
01/2020
1alpha-Thalassemia
01/2019

Drug/Important Bio-Agent (IBA)

13Proteins (Proteins, Gene)FDA Link
12/2022 - 06/2003
13Amyloid Precursor Protein Secretases (beta-Secretase)IBA
01/2022 - 07/2004
10LigandsIBA
12/2021 - 10/2004
8Notch ReceptorsIBA
01/2020 - 01/2003
6AntigensIBA
01/2021 - 06/2006
6RNA (Ribonucleic Acid)IBA
01/2021 - 04/2004
6Transcription Factors (Transcription Factor)IBA
11/2019 - 02/2007
5Phosphotransferases (Kinase)IBA
01/2021 - 02/2014
5Biomarkers (Surrogate Marker)IBA
10/2018 - 10/2014
4CytokinesIBA
01/2021 - 09/2014
4Pharmaceutical PreparationsIBA
11/2016 - 02/2003
3Cyclophosphamide (Cytoxan)FDA LinkGeneric
12/2022 - 01/2002
3AntibodiesIBA
10/2019 - 02/2010
3ChromatinIBA
01/2019 - 01/2014
3Biological ProductsIBA
01/2019 - 11/2012
3Oncogene Proteins (Oncogene Protein)IBA
02/2014 - 02/2004
3Notch1 ReceptorIBA
02/2008 - 11/2004
2Vincristine (Oncovin)FDA LinkGeneric
12/2022 - 01/2002
2Doxorubicin (Adriamycin)FDA LinkGeneric
12/2022 - 01/2002
2Prednisone (Sone)FDA LinkGeneric
12/2022 - 01/2002
2Serine (L-Serine)FDA Link
12/2021 - 01/2010
2Threonine (L-Threonine)FDA Link
12/2021 - 01/2010
2Platelet-Derived Growth Factor beta Receptor (Receptor, Platelet Derived Growth Factor beta)IBA
04/2020 - 12/2003
2GenieIBA
01/2020 - 01/2019
2DNA (Deoxyribonucleic Acid)IBA
11/2019 - 04/2004
2Small Interfering RNA (siRNA)IBA
01/2019 - 10/2012
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
10/2018 - 02/2007
2Sirolimus (Rapamycin)FDA Link
01/2018 - 07/2007
2VaccinesIBA
01/2018 - 01/2017
2Protein Kinases (Protein Kinase)IBA
05/2017 - 01/2010
2Syk KinaseIBA
01/2016 - 02/2014
2Monoclonal AntibodiesIBA
06/2015 - 07/2009
2Complementary DNA (cDNA)IBA
03/2013 - 02/2008
2Polychlorinated Biphenyls (PCBs)IBA
05/2010 - 03/2010
2Dichlorodiphenyl Dichloroethylene (DDE)IBA
05/2010 - 03/2010
2Nuclear Proteins (Protein, Nuclear)IBA
07/2009 - 06/2008
2Cyclin D3IBA
02/2009 - 12/2003
2Green Fluorescent ProteinsIBA
04/2006 - 02/2003
2PresenilinsIBA
07/2004 - 01/2003
1Rituximab (Mabthera)FDA Link
12/2022
1carboxyl radical (COO-)IBA
12/2022
1Proline (L-Proline)FDA Link
12/2021
1Glutamic Acid (Glutamate)FDA Link
12/2021
1chenodeoxycholate sulfate conjugate (CDCS)IBA
01/2021
1Bacterial ToxinsIBA
01/2021
1tyrosine receptor (receptor, tyrosine)IBA
01/2021
1Small Cytoplasmic RNAIBA
01/2021
1LipidsIBA
10/2020
12- (1H- indazol- 4- yl)- 6- (4- methanesulfonylpiperazin- 1- ylmethyl)- 4- morpholin- 4- ylthieno(3,2- d)pyrimidineIBA
01/2020
1GlucocorticoidsIBA
01/2020
1Core Binding Factors (Core-Binding Factor)IBA
01/2020
1Dexamethasone (Maxidex)FDA LinkGeneric
01/2020
1Glucocorticoid Receptors (Glucocorticoid Receptor)IBA
01/2020
1Azacitidine (5 Azacytidine)FDA Link
11/2019
1Interleukin-3 Receptors (Interleukin 3 Receptor)IBA
11/2019
1tagraxofuspIBA
11/2019
1Alemtuzumab (Campath)FDA Link
01/2019
1Toll-Like Receptors (Toll-Like Receptor)IBA
01/2019
1InterferonsIBA
01/2019

Therapy/Procedure

23Therapeutics
01/2021 - 07/2004
4Drug Therapy (Chemotherapy)
11/2018 - 01/2002
2Immunotherapy
01/2021 - 01/2016
1Nephrectomy
01/2019